Holger Stark Selected Research

Histamine H4 Receptors

1/2021	Eosinophils adhesion assay as a tool for phenotypic drug screening - The pharmacology of 1,3,5 - Triazine and 1H-indole like derivatives against the human histamine H4 receptor.
4/2019	Human β-Defensin 2 Expression in Oral Epithelium: Potential Therapeutic Targets in Oral Lichen Planus.
12/2018	Differential effects of functionally different histamine H4 receptor ligands on acute irritant dermatitis in mice.
1/2018	Antinociceptive effects of novel histamine H3 and H4 receptor antagonists and their influence on morphine analgesia of neuropathic pain in the mouse.
10/2017	From medicinal plant extracts to defined chemical compounds targeting the histamine H4 receptor: Curcuma longa in the treatment of inflammation.
8/2016	Allergic inflammation is augmented via histamine H4 receptor activation: The role of natural killer cells in vitro and in vivo.
1/2016	Role of histamine H4 receptor ligands in bleomycin-induced pulmonary fibrosis.
12/2015	Histamine H4 receptor activation alleviates neuropathic pain through differential regulation of ERK, JNK, and P38 MAPK phosphorylation.
11/2014	Prevention of bleomycin-induced lung inflammation and fibrosis in mice by naproxen and JNJ7777120 treatment.
1/2009	Histamine H4 receptor antagonism reduces hapten-induced scratching behaviour but not inflammation.

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Holger Stark Research Topics

Disease

19	Inflammation (Inflammations) 01/2022 - 01/2009
13	Neoplasms (Cancer) 01/2022 - 02/2012
11	Schizophrenia (Dementia Praecox) 03/2022 - 10/2002
10	Alzheimer Disease (Alzheimer's Disease) 11/2021 - 05/2012
10	Parkinson Disease (Parkinson's Disease) 01/2021 - 10/2002
9	Pain (Aches) 01/2022 - 10/2010
9	Narcolepsy 06/2021 - 05/2012
9	Epilepsy (Aura) 01/2020 - 10/2009
7	Neurodegenerative Diseases (Neurodegenerative Disease) 12/2021 - 10/2016
5	Autistic Disorder (Autism) 06/2021 - 10/2019
5	Pruritus (Itching) 01/2021 - 03/2009
5	Neuralgia (Stump Neuralgia) 01/2018 - 10/2009
4	Hematologic Neoplasms (Hematological Malignancy) 01/2022 - 08/2016
4	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 01/2022 - 10/2014
4	Asthma (Bronchial Asthma) 01/2021 - 10/2011
4	Cognitive Dysfunction 01/2021 - 10/2009
4	Autoimmune Diseases (Autoimmune Disease) 09/2020 - 10/2011
4	Seizures (Absence Seizure) 01/2020 - 06/2014
3	Psychotic Disorders (Schizoaffective Disorder) 03/2022 - 10/2002
3	Autism Spectrum Disorder 02/2022 - 10/2019
3	Multiple Sclerosis 01/2022 - 10/2014
3	Memory Disorders (Memory Loss) 06/2021 - 01/2018
3	Nervous System Diseases (Neurological Disorders) 04/2021 - 05/2012
3	Atopic Dermatitis (Atopic Eczema) 01/2021 - 03/2009
3	Allergic Rhinitis 01/2021 - 10/2010
3	Dyskinesias (Dyskinesia) 01/2021 - 06/2003
3	Disorders of Excessive Somnolence (Hypersomnia) 03/2019 - 11/2012
3	Immune System Diseases (Immune Disorders) 01/2017 - 11/2014
3	Skin Diseases (Skin Disease) 11/2016 - 10/2009
3	Hypersensitivity (Allergy) 01/2015 - 05/2005
2	Mental Disorders (Mental Disorder) 03/2022 - 08/2003
2	Graft vs Host Disease (Graft-Versus-Host Disease) 01/2022 - 05/2017
2	Breast Neoplasms (Breast Cancer) 01/2022 - 08/2015
2	Prader-Willi Syndrome (Syndrome, Prader-Willi) 11/2020 - 03/2019
2	Neuroblastoma 05/2020 - 01/2018
2	Obesity 04/2020 - 06/2017
2	Edema (Dropsy) 12/2018 - 08/2014
2	Dermatitis 08/2016 - 01/2009
2	Relapsing-Remitting Multiple Sclerosis 01/2016 - 10/2014
2	Pulmonary Fibrosis (Fibrosing Alveolitis) 01/2016 - 11/2014
2	Fibrosis (Cirrhosis) 01/2016 - 11/2014
2	Stomach Ulcer (Gastric Ulcer) 07/2015 - 01/2012

Drug/Important Bio-Agent (IBA)

25	Histamine (Histamine Dihydrochloride)FDA Link 06/2021 - 05/2005
24	LigandsIBA 03/2022 - 04/2005
15	Histamine H3 Receptors (Histamine H3 Receptor)IBA 12/2021 - 07/2013
11	Pharmaceutical PreparationsIBA 01/2021 - 04/2005
10	Histamine H4 ReceptorsIBA 01/2021 - 01/2009
8	Proteins (Proteins, Gene)FDA Link 11/2020 - 01/2006
7	Dopamine (Intropin)FDA LinkGeneric 03/2022 - 10/2002
6	pitolisantIBA 01/2021 - 11/2012
5	Monoamine Oxidase (MAO)IBA 06/2021 - 10/2017
5	Fingolimod Hydrochloride (FTY720)FDA Link 01/2021 - 10/2014
4	Neurotransmitter Agents (Neurotransmitter)IBA 03/2022 - 01/2020
4	EnzymesIBA 06/2021 - 06/2013
4	Acetylcholine (Acetylcholine Chloride)FDA Link 06/2021 - 10/2019
4	Anticonvulsants (Antiepileptic Drugs)IBA 01/2020 - 01/2016
4	1- ((5- chloro- 1H- indol- 2- yl)carbonyl)- 4- methylpiperazineIBA 12/2018 - 01/2009
3	Biological ProductsIBA 02/2022 - 06/2013
3	Sphingosine-1-Phosphate ReceptorsIBA 01/2022 - 06/2015
3	Levodopa (L Dopa)FDA LinkGeneric 01/2021 - 06/2003
3	EsterasesIBA 06/2020 - 10/2019
3	imidazoleIBA 04/2020 - 01/2018
3	Pentylenetetrazole (Metrazol)IBA 01/2020 - 01/2018
3	Cytochrome P-450 CYP3AIBA 06/2019 - 08/2014
3	CytokinesIBA 08/2016 - 03/2009
2	Serotonin (5 Hydroxytryptamine)IBA 03/2022 - 02/2022
2	cariprazineIBA 03/2022 - 01/2018
2	AntioxidantsIBA 02/2022 - 01/2018
2	Retinaldehyde (Retinal)IBA 01/2022 - 01/2006
2	siponimodIBA 01/2022 - 09/2020
2	Scopolamine (Hyoscine)FDA Link 06/2021 - 01/2018
2	Cholinesterases (Cholinesterase)IBA 01/2021 - 10/2017
2	sphingosine 1-phosphate (sphingosine-1-phosphate)IBA 01/2021 - 01/2017
2	Therapeutic UsesIBA 11/2020 - 06/2003
2	GTP-Binding Proteins (G-Protein)IBA 11/2020 - 01/2018
2	Valproic Acid (Depakote)FDA LinkGeneric 06/2020 - 10/2019
2	ciproxifanIBA 02/2019 - 11/2012
2	CarrageenanIBA 01/2019 - 08/2014
2	Formaldehyde (Formol)FDA Link 01/2019 - 01/2018
2	N4- (2,6- dichlorobenzyl)- 6- (4- methylpiperazin- 1- yl)pyrimidine- 2,4- diamineIBA 12/2018 - 12/2015
2	ChemokinesIBA 06/2018 - 01/2015
2	CeramidesIBA 05/2017 - 02/2012
2	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2017 - 08/2016
2	Arachidonate 5-Lipoxygenase (5 Lipoxygenase)IBA 01/2017 - 01/2015
2	Histamine Receptors (Histamine Receptor)IBA 11/2016 - 12/2015
2	CollagenIBA 01/2016 - 11/2014
2	7a- (4- octylphenethyl)tetrahydro- 1H- oxazolo(3,4- c)oxazoleIBA 01/2016 - 10/2014
2	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2016 - 11/2014
2	Bleomycin (Blenoxane)FDA LinkGeneric 01/2016 - 11/2014
2	LeukotrienesIBA 01/2015 - 09/2014
2	Arachidonic Acid (Vitamin F)IBA 01/2015 - 09/2014
2	Messenger RNA (mRNA)IBA 01/2015 - 03/2009
1	Amphetamine (Amfetamine)FDA LinkGeneric 03/2022
1	N-dodecyl-L-lysine amideIBA 03/2022
1	Serotonin ReceptorsIBA 03/2022
1	Antipsychotic Agents (Antipsychotics)IBA 03/2022
1	serotonin 7 receptorIBA 02/2022

Therapy/Procedure

9	Therapeutics 01/2022 - 06/2003
2	Immunotherapy 01/2022 - 05/2017
2	Cell Transplantation 01/2022 - 05/2017